• J L Willems
  • J P Langenberg
  • A G Verstraete
  • M De Loose
  • B Vanhaesebroeck
  • G Goethals
  • F M Belpaire
  • W A Buylaert
  • D Vogelaers
  • F Colardyn

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Using pharmacokinetic data from healthy human volunteers in a bicompartmental pharmacokinetic model, a repeated dose scheme for pralidoxime methylsulphate (Contrathion) was developed producing plasma levels remaining above the assumed "therapeutic concentration" of 4 mg.l-1. Using the same data, it was found that a concentration of 4 mg.l-1 could also be obtained by a loading dose of 4.42 mg.kg-1 followed by a maintenance dose of 2.14 mg.kg-1.h-1. In order to study the pharmacokinetic behaviour of pralidoxime in poisoned patients, this continuous infusion scheme was then applied in nine cases of organophosphorus poisoning (agents: ethyl parathion, ethyl and methyl parathion, dimethoate and bromophos), and the pralidoxime plasma levels were determined. The mean plasma levels obtained in the various patients varied between 2.12 and 9 mg.l-1. Pharmacokinetic data were calculated, giving a total body clearance of 0.57 +/- 0.27 l.kg-1.h-1 (mean +/- SD), an elimination half-life of 3.44 +/- 0.90 h, and a volume of distribution of 2.77 +/- 1.45 l.kg-1.
Originele taal-2Engels
TijdschriftArchives of Toxicology
Volume66
Nummer van het tijdschrift4
Pagina's (van-tot)260-6
Aantal pagina's7
ISSN0340-5761
StatusGepubliceerd - 1992

ID: 552782